Understanding Heat Shock Protein Complex Vaccines

Grant number: LP120100226 | Funding period: 2012 - 2015

Completed

Abstract

This project aims to understand the mechanism of action and formulation requirements of a novel vaccine technology that utilises heat shock protein complexes. By understanding how this technology works, future vaccines can be improved to induce the immune response required to target specific pathogens, as well as give assurance regarding its safety.

Related publications (4)

Activation of TRIF-dependent and independent immune responses by neisserial heat shock protein complex vaccines

GZ Ng, JX Han, CA Colaco, P Sutton

2016-11-01

ASBTRACT: Heat shock protein Complex (HspC) vaccines are composed of Hsp purified from pathogenic bacteria along with their chaper..

Heat shock protein complex vaccines induce antibodies against Neisseria meningitidis via a MyD88-independent mechanism

JX Han, GZ Ng, P Cecchini, YT Chionh, MA Saeed, LM Næss, M Joachim, LE Blandford, RA Strugnell, CA Colaco, P Sutton

2016-03-29

Background: Neisseria meningitidis are common colonizers of the human nasopharynx. In some circumstances, N. meningitidis becomes ..

Heat shock protein complex vaccination induces protection against Helicobacter pylori without exogenous adjuvant

YT Chionh, A Arulmuruganar, E Venditti, GZ Ng, JX Han, C Entwisle, CS Ang, CA Colaco, S McNulty, P Sutton

2014-04-25

Background: The development of a vaccine against the human gastric pathogen Helicobacter pylori, the main causative agent of gastr..

Why can't we make an effective vaccine against Helicobacter pylori?

P Sutton, YT Chionh

2013-04-01

Helicobacter pylori is a major human pathogen that colonizes the stomach and is the lead etiological agent for several pathologies..

University of Melbourne Researchers

Phil Sutton